[HTML][HTML] DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation
O Hopfer, M Komor, IS Koehler, M Schulze… - Experimental …, 2007 - Elsevier
Deregulated epigenetic mechanisms are likely involved in the pathogenesis of
myelodysplastic syndromes (MDSs). Which genes are silenced by aberrant promotor
methylation during MDS hematopoiesis has not been equivalently investigated. Using an in
vitro differentiation model of human hematopoiesis, we generated defined differentiation
stages (day 0, day 4, day 7, day 11) of erythro-, thrombo-and granulopoiesis from 13 MDS
patients and seven healthy donors. Promotor methylation analysis of key regulatory genes …
myelodysplastic syndromes (MDSs). Which genes are silenced by aberrant promotor
methylation during MDS hematopoiesis has not been equivalently investigated. Using an in
vitro differentiation model of human hematopoiesis, we generated defined differentiation
stages (day 0, day 4, day 7, day 11) of erythro-, thrombo-and granulopoiesis from 13 MDS
patients and seven healthy donors. Promotor methylation analysis of key regulatory genes …
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